Most of the cholesterol used by active adults is produced in the liver, which produces ~70% of daily cholesterol demand (~1 gram). The molecule is unsaturated at position 5,6 with an alkene group. Your liver makes all the cholesterol you need. Note that significant amounts of cholesterol only occur in meat, eggs, and milk products; plants and mushrooms contain other sterols but very little cholesterol. Cholesterol is a waxy substance. Cholesterol can also be obtained from food. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D.Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts. Where is cholesterol synthesized? Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. But too much cholesterol can pose a problem. Acetyl-CoA is produced from glucose by the same sequence of reactions used to produce cytosolic acetyl-CoA for fatty acid biosynthesis. Cholesterol is a tetracyclic alcohol and a type of sterol.Added to the sterol frame with the alcohol group at position 3 are 2 methyl groups at carbon positions 10 and 13 and a 2-isooctyl group at position 17. The primary bile acids are synthesized in the liver from cholesterol. A typical North American diet contains approximately 450mg of cholesterol per day (of which 55% is absorbed), while cholesterol synthesis on such a modest cholesterol diet is 11–13mg/kg/day. Cholesterol is synthesized from cytosolic acetyl-CoA by a sequence of reactions: Glucose is a major source of carbon for acetyl-CoA. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as Mycoplasma, which require cholesterol for growth. The molecule. It is synthesized from simpler substances within the body. Cholesterol comes from two sources. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the total daily cholesterol requirement (~1 gram). The other 30% originates from dietary absorption. Expert Answer . The remainder of the cholesterol in your body comes from foods from animals. Cholesterol is synthesized by virtually all tissues in human, although liver, intestine, adrenal cortex, reproductive organs (testis and ovaries) and placenta make largest contributions to the body’s cholesterol pool. Previous question Next question Get more help from Chegg. Cholesterol is essential for all living organisms. Biosynthesis of cholesterol commonly happens in the endoplasmic reticulum of hepatic cells. Cholesterol levels in the body originate from its biosynthesis and diet. Cholesterol is present in tissues and in plasma either as free cholesterol or combined with a long-chain fatty acid as cholesteryl ester, the storage form. 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